Lilly drug chosen for Alzheimer's prevention study

Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.

The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.

Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.

"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.

She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.

In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.

Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.

About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.

___

Online:

Alzheimer's info: http://www.alzheimers.gov

Alzheimer's Association: http://www.alz.org

___

Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP

Read More..

Wall Street Week Ahead: Earnings, money flows to push stocks higher

NEW YORK (Reuters) - With earnings momentum on the rise, the S&P 500 seems to have few hurdles ahead as it continues to power higher, its all-time high a not-so-distant goal.

The U.S. equity benchmark closed the week at a fresh five-year high on strong housing and labor market data and a string of earnings that beat lowered expectations.

Sector indexes in transportation <.djt>, banks <.bkx> and housing <.hgx> this week hit historic or multiyear highs as well.

Michael Yoshikami, chief executive at Destination Wealth Management in Walnut Creek, California, said the key earnings to watch for next week will come from cyclical companies. United Technologies reports on Wednesday while Honeywell is due to report Friday.

"Those kind of numbers will tell you the trajectory the economy is taking," Yoshikami said.

Major technology companies also report next week, but the bar for the sector has been lowered even further.

Chipmakers like Advanced Micro Devices , which is due Tuesday, are expected to underperform as PC sales shrink. AMD shares fell more than 10 percent Friday after disappointing results from its larger competitor, Intel . Still, a chipmaker sector index <.sox> posted its highest weekly close since last April.

Following a recent underperformance, an upside surprise from Apple on Wednesday could trigger a return to the stock from many investors who had abandoned ship.

Other major companies reporting next week include Google , IBM , Johnson & Johnson and DuPont on Tuesday, Microsoft and 3M on Thursday and Procter & Gamble on Friday.

CASH POURING IN, HOUSING DATA COULD HELP

Perhaps the strongest support for equities will come from the flow of cash from fixed income funds to stocks.

The recent piling into stock funds -- $11.3 billion in the past two weeks, the most since 2000 -- indicates a riskier approach to investing from retail investors looking for yield.

"From a yield perspective, a lot of stocks still yield a great deal of money and so it is very easy to see why money is pouring into the stock market," said Stephen Massocca, managing director at Wedbush Morgan in San Francisco.

"You are just not going to see people put a lot of money to work in a 10-year Treasury that yields 1.8 percent."

Housing stocks <.hgx>, already at a 5-1/2 year high, could get a further bump next week as investors eye data expected to support the market's perception that housing is the sluggish U.S. economy's bright spot.

Home resales are expected to have risen 0.6 percent in December, data is expected to show on Tuesday. Pending home sales contracts, which lead actual sales by a month or two, hit a 2-1/2 year high in November.

The new home sales report on Friday is expected to show a 2.1 percent increase.

The federal debt ceiling negotiations, a nagging worry for investors, seemed to be stuck on the back burner after House Republicans signaled they might support a short-term extension.

Equity markets, which tumbled in 2011 after the last round of talks pushed the United States close to a default, seem not to care much this time around.

The CBOE volatility index <.vix>, a gauge of market anxiety, closed Friday at its lowest since April 2007.

"I think the market is getting somewhat desensitized from political drama given, this seems to be happening over and over," said Destination Wealth Management's Yoshikami.

"It's something to keep in mind, but I don't think it's what you want to base your investing decisions on."

(Reporting by Rodrigo Campos, additional reporting by Chuck Mikolajczak and Caroline Valetkevitch; Editing by Kenneth Barry)

Read More..

British Leader Sees Wider Threat in Algeria Attack

Oli Scarff/Getty Images

Prime Minister David Cameron en route to Parliament to deliver a statement on the Algeria hostage crisis.

LONDON — With more than 60 hostages still missing and many feared dead, Prime Minister David Cameron told Parliament on Friday that the Qaeda-linked attack on a remote Algerian gas installation demonstrated the need for Britain and its Western allies, including the United States, to direct more of their diplomatic, military and intelligence resources to the intensifying threat emanating from “the ungoverned space” of the North African desert, treating it with as much concern as the terrorist challenge in Pakistan and Afghanistan.

Mr. Cameron offered little new information about the showdown at the In Amenas plant, nearly 1,000 miles from Algiers, the Algerian capital, in the oil-and-gas-rich emptiness of the Sahara, saying the information reaching London about what he described as a “continuing situation” remained sketchy. He added that Britain learned overnight that the number of British citizens caught up in the hostage-taking and the subsequent shootout was “significantly” fewer than the 30 people feared on Thursday. As part of the effort to learn more, he said, a special plane had been assigned to carry Britain’s ambassador in Algiers and other British diplomats to the area of the gas plant on Friday.

But in an hourlong session in the House of Commons, Mr. Cameron pointed to the somber implications of underestimating recent events in Mali and Algeria as a regional problem for North Africa rather than as an increasingly fertile arena for Islamic militants and their hostility to the West. He said he had discussed his concerns in a telephone conversation with President Obama on Thursday.

The British leader said the growth of Islamic terrorist networks in the countries of the Sahel, the broad area of North Africa that runs more than 3,000 miles from Mauritania in the west to Sudan and Somalia in the east, should be a renewed focus of Western counterterrorist concerns and resources. At one point, he said military assistance to the affected countries needed to be part of NATO military planning, though he again emphatically ruled out any British combat role in support of France’s campaign against militants in Mali.

Pointing to the leading role played in the Algerian attack by Mokhtar Belmokhtar, a terrorist ringleader and smuggler with links to North Africa’s main Islamic terrorist group, Al Qaeda in the Islamic Maghreb, Mr. Cameron warned that the Algerian attack was symptomatic of a far broader threat.

“What we know is that the terrorist threat in the Sahel comes from Al Qaeda in the Islamic Maghreb, which aspires to establish Islamic law across the Sahel and northern Africa, and to attack Western interests in the region and, frankly, wherever it can,” Mr. Cameron said. “Just as we have reduced the scale of the Al Qaeda threat in other parts of the world, including in Pakistan and Afghanistan, so it has grown in other parts of the world. We need to be equally concerned about that, and equally focused on it.”

To some British commentators, Mr. Cameron’s remarks sounded like an effort to prompt the United States to become more deeply involved in North African security matters. In the 2011 Libyan conflict, the United States stepped back from the lead role it has traditionally taken in NATO military operations and left Britain, France and Italy to conduct the bulk of the bombing in support of the Libyan rebels’ successful campaign to topple Col. Muammar el-Qaddafi.

Since then, high-ranking British officials have expressed concerns that the Obama administration is stepping back from European political and security issues and turning its attentions increasingly to the nations of the Pacific.

With the approach of Mr. Obama’s second inauguration on Sunday, The Spectator, a London-based weekly that is influential in Mr. Cameron’s Conservative Party, devoted its cover this week to an article headlined “The Pacific President,” and an illustration showing Mr. Obama in a brightly colored Hawaiian shirt and shorts surfing off a palm-lined beach. “As Barack Obama is sworn in again as president, his allies in the West will ask themselves the same nervous question they posed four years ago: how much does he care about us?” the accompanying article asked.

White House officials said on Thursday that Mr. Obama had used his telephone conversation with Mr. Cameron to underscore American concerns that Britain remain a robust force within the 27-nation European Union, a hot-button issue for Mr. Cameron. The prime minister had planned — then canceled, amid the Algerian crisis — a landmark speech in Amsterdam on Friday in which he was to have outlined his plan to negotiate a much sparer role for Britain in the European bloc.

In his remarks to lawmakers on Friday, Mr. Cameron offered what could have been construed as an oblique riposte to Mr. Obama, or at least to officials in the Obama administration who have urged that Europe take greater responsibility for confronting terrorist and other security threats at its own doorstep.  He may also have been addressing domestic critics in Britain, or other NATO countries that have been less active than Britain in counterterrorism efforts aimed at confronting the spread of Islamic militant groups.

“There is a great need for not just Britain but other countries to give a priority to understanding better, and working better, with the countries in this region,” he said. “Those who believe that there is a terrorist, extremist Al Qaeda problem in parts of north Africa, but that it is a problem for those places and we can somehow back off and ignore it, are profoundly wrong. That is a problem for those places, and for us.”

Mr. Cameron noted that Britain had been “the first country in the world” to offer France military assistance in its campaign in Mali, deploying one of the largest military transport aircraft it has, an American-made C-17 Globemaster, to ferry French troops and military equipment to Bamako, the Malian capital. He said it was time for Britain and France to move beyond their spheres of influence in Africa dating back to the colonial era, “and recognize that is in our interest to boost the capacity of all African states” confronted by the terrorist threat.

This article has been revised to reflect the following correction:

Correction: January 18, 2013

An earlier version of this article misstated the year that Libyan rebels overthrew Col. Muammar el-Qaddafi. It was 2011, not last year.

Read More..

RIM offers Android developers up to $2,000 to port apps to BlackBerry 10 this weekend

RIM (RIMM) really wants Android developers to bring their apps over to BlackBerry 10, and it’s got the cash to prove it. Via AndroidGuys, it seems that RIM will hold a “BlackBerry 10 Last Chance Port-A-Thon” that will pay Android developers $ 100 for every approved app they port over to BlackBerry 10, with a limite of 20 different paid apps per developer. RIM says that the “port-a-thon” will start at noon Friday and run for the following 36 hours. App developers have shown some strong interest in BlackBerry 10 so far as RIM announced this week that it had received 15,000 app submission over just two days during the last port-a-thon, although the company didn’t mention how much influence its “really cool” SDK had in convincing companies to develop for its new platform.

[More from BGR: Samsung’s latest monster smartphone will reportedly have a 5.8-inch screen]

This article was originally published on BGR.com

Gadgets News Headlines – Yahoo! News

Read More..

The Wire's Robert F. Chew Dies of Heart Failure

01/18/2013 at 06:30 PM EST

Robert F. Chew, best known for his role on the hit HBO show The Wire, has died from heart failure, according to The Baltimore Sun. He was 52.

Chew, who played Proposition Joe on the cable show, passed away in his sleep on Thursday at his home in Baltimore, his sister Clarise Chew tells the paper.

His former co-star Michael Kenneth Wiliams Tweeted a message on Thursday saying, "R.I.P. to the talented Mr Robert Chew." The message was retweeted almost 1,000 times and was met by shock and sadness from friends and fans.

"I didn't want to believe this #RIP Robert F Chew," The Wire's Jamie Hector wrote on Twitter. "Prop Joe will always be remembered Robert Chew will always be loved and missed!"

The show's creator, David Simon, sent a lengthy email to The Baltimore Sun praising Chew's work as an actor and his dedication to his community.

"Robert was not only an exceptional actor, he was an essential part of the film and theater community in Baltimore," wrote David Simon. "He could have gone to New York or Los Angeles and commanded a lot more work, but he loved the city as his home and chose to remain here working."

Chew, a member of the local Arena Players theater troupe, mentored children and aspiring actors, and even facilitated bringing a group of 22 young actors to play students on The Wire's fourth season.

Read More..

Flu season 'bad one for the elderly,' CDC says

The number of older people hospitalized with the flu has risen sharply, prompting federal officials to take unusual steps to make more flu medicines available and to urge wider use of them as soon as symptoms appear.

The U.S. is about halfway through this flu season, and "it's shaping up to be a worse-than-average season" and a bad one for the elderly, said Dr. Thomas Frieden, director of the Centers for Disease Control and Prevention.

It's not too late to get a flu shot, and "if you have symptoms, please stay home from work, keep your children home from school" and don't spread the virus, he said.

New figures from the CDC show widespread flu activity in all states but Tennessee and Hawaii. Some parts of the country are seeing an increase in flu activity "while overall activity is beginning to go down," Frieden said. Flu activity is high in 30 states and New York City, up from 24 the previous week.

Nine more children or teens have died of the flu, bringing the nation's total this flu season to 29. That's close to the 34 pediatric deaths reported during all of the last flu season, although that one was unusually light. In a typical season, about 100 children die of the flu and officials said there is no way to know whether deaths this season will be higher or lower than usual.

The government doesn't keep a running tally of adult deaths from the flu, but estimates that it kills about 24,000 people most years.

So far, half of confirmed flu cases are in people 65 and older. Lab-confirmed flu hospitalizations totaled 19 for every 100,000 in the population, but 82 per 100,000 among those 65 and older, "which is really quite a high rate," Frieden said.

"We expect to see both the number and the rates of both hospitalizations and deaths rise further in the next week or so as the flu epidemic progresses,'" so prompt treatment is key to preventing deaths, he said.

About 90 percent of flu deaths are in the elderly; the very young and people with other health problems such as diabetes are also at higher risk.

If you're worried about how sick you are and are in one of these risk groups, see a doctor, Frieden urged. One third to one half of people are not getting prompt treatment with antiviral medicines, he said.

Two drugs — Tamiflu and Relenza — can cut the severity and risk of death from the flu but must be started within 48 hours of first symptoms to do much good. Tamiflu is available in a liquid form for use in children under 1, and pharmacists can reformulate capsules into a liquid if supplies are short in an area, said Dr. Margaret Hamburg, head of the Food and Drug Administration.

To help avoid a shortage, the FDA is letting Tamiflu's maker, Genentech, distribute 2 million additional doses of capsules that have an older version of package insert.

"It is fully approved, it is not outdated," just lacks information for pharmacists on how to mix it into a liquid if needed for young children, she said.

This year's flu season started about a month earlier than normal and the dominant flu strain is one that tends to make people sicker. Vaccinations are recommended for anyone 6 months or older. There's still plenty of vaccine — an update shows that 145 million doses have been produced, "twice the supply that was available only several years ago," Hamburg said.

About 129 million doses have been distributed already, and a million doses are given each day, Frieden said. The vaccine is not perfect but "it's by far the best tool we have to prevent influenza," he said.

Carlos Maisonet, 73, got a flu shot this week at New York's Brooklyn Hospital Center at the urging of his wife, who was vaccinated in August.

"This is his first time getting the flu shot," said his wife, Zulma Ramos.

Last week, the CDC said the flu again surpassed an "epidemic" threshold, based on monitoring of deaths from flu and a frequent complication, pneumonia. The flu epidemic happens every year and officials say this year's vaccine is a good match for strains that are going around.

___

Online:

Flu vaccine finder: http://www.flu.gov

CDC flu info: http://www.cdc.gov/flu/index.htm

___

AP Photographer Bebeto Matthews in New York contributed to this report.

___

Follow Marilynn Marchione's coverage at —http://twitter.com/MMarchioneAP

Read More..

Wall Street Week Ahead: Earnings, money flows to push stocks higher

NEW YORK (Reuters) - With earnings momentum on the rise, the S&P 500 seems to have few hurdles ahead as it continues to power higher, its all-time high a not-so-distant goal.

The U.S. equity benchmark closed the week at a fresh five-year high on strong housing and labor market data and a string of earnings that beat lowered expectations.

Sector indexes in transportation <.djt>, banks <.bkx> and housing <.hgx> this week hit historic or multiyear highs as well.

Michael Yoshikami, chief executive at Destination Wealth Management in Walnut Creek, California, said the key earnings to watch for next week will come from cyclical companies. United Technologies reports on Wednesday while Honeywell is due to report Friday.

"Those kind of numbers will tell you the trajectory the economy is taking," Yoshikami said.

Major technology companies also report next week, but the bar for the sector has been lowered even further.

Chipmakers like Advanced Micro Devices , which is due Tuesday, are expected to underperform as PC sales shrink. AMD shares fell more than 10 percent Friday after disappointing results from its larger competitor, Intel . Still, a chipmaker sector index <.sox> posted its highest weekly close since last April.

Following a recent underperformance, an upside surprise from Apple on Wednesday could trigger a return to the stock from many investors who had abandoned ship.

Other major companies reporting next week include Google , IBM , Johnson & Johnson and DuPont on Tuesday, Microsoft and 3M on Thursday and Procter & Gamble on Friday.

CASH POURING IN, HOUSING DATA COULD HELP

Perhaps the strongest support for equities will come from the flow of cash from fixed income funds to stocks.

The recent piling into stock funds -- $11.3 billion in the past two weeks, the most since 2000 -- indicates a riskier approach to investing from retail investors looking for yield.

"From a yield perspective, a lot of stocks still yield a great deal of money and so it is very easy to see why money is pouring into the stock market," said Stephen Massocca, managing director at Wedbush Morgan in San Francisco.

"You are just not going to see people put a lot of money to work in a 10-year Treasury that yields 1.8 percent."

Housing stocks <.hgx>, already at a 5-1/2 year high, could get a further bump next week as investors eye data expected to support the market's perception that housing is the sluggish U.S. economy's bright spot.

Home resales are expected to have risen 0.6 percent in December, data is expected to show on Tuesday. Pending home sales contracts, which lead actual sales by a month or two, hit a 2-1/2 year high in November.

The new home sales report on Friday is expected to show a 2.1 percent increase.

The federal debt ceiling negotiations, a nagging worry for investors, seemed to be stuck on the back burner after House Republicans signaled they might support a short-term extension.

Equity markets, which tumbled in 2011 after the last round of talks pushed the United States close to a default, seem not to care much this time around.

The CBOE volatility index <.vix>, a gauge of market anxiety, closed Friday at its lowest since April 2007.

"I think the market is getting somewhat desensitized from political drama given, this seems to be happening over and over," said Destination Wealth Management's Yoshikami.

"It's something to keep in mind, but I don't think it's what you want to base your investing decisions on."

(Reporting by Rodrigo Campos, additional reporting by Chuck Mikolajczak and Caroline Valetkevitch; Editing by Kenneth Barry)

Read More..

China Objects After Shell Is Fired From Myanmar

BANGKOK — China said Thursday that it had expressed “grave concern” to the Myanmar government after a shell, apparently fired during fighting between Myanmar troops and ethnic rebels, landed in Chinese territory, and a Chinese government spokesman called for an immediate cease-fire.

The Chinese response was unusually strong given the close ties between the two countries in recent years, and it suggested that China was growing increasingly impatient and nervous about the fighting between ethnic Kachin rebels and Myanmar government troops.

“China has lodged urgent representation to Myanmar over the incident, to express grave concerns and dissatisfaction,” said Hong Lei, a spokesman for China’s Foreign Ministry, who called for a cease-fire, according to the official Xinhua news agency.

Xinhua said the artillery shell was the fourth “bomb” dropped inside China in recent months. Three others landed on Chinese territory on Dec. 30.

Myanmar troops are pressing toward the headquarters of the Kachin Independence Army in Laiza, a town along the border with China.

Myanmar’s government has repeatedly said that it wants to negotiate with the Kachin rebels. “We want to reduce our offensive and return to talks,” U Ye Htut, a spokesman for President Thein Sein, said in an interview with the online news site The Irrawaddy that was posted on Thursday.

But the military appears to be accelerating its campaign against the Kachin, using heavy artillery, attack helicopters and other aircraft to flush out guerrillas from their positions surrounding Laiza.

The Kachin rebels still control portions of territory along the border with China, including areas where Chinese companies own plantations.

Read More..

The aggressively priced Lumia 620 is Nokia’s make or break model

Nokia (NOK) has started pricing the Lumia 620 in Asia nearly 20% below the rival Windows mid-market model, the HTC (2498) 8S. This is remarkably aggressive considering the 620 has a higher pixel density and twice as much internal memory. The 620 is the keystone phone for Nokia. It is launching before RIM (RIMM) gets its new budget BlackBerry phones out and before Samsung (005930) or LG (066570) enter the mid-priced Windows phone market. This is the phone that will make or break Nokia’s summer.

[More from BGR: BlackBerry 10 browser smokes iOS 6 and Windows Phone 8 in comparison test [video]]

Nokia has started rolling out the Lumia 620 in several key Asian markets by the third week of January. It now looks like its European debut could happen a few weeks earlier than expected, perhaps by the end of January. In one of the earliest launch markets, Thailand, the launch price of the Lumia 620 is set at 8,250 baht, or $ 275. The only direct Windows mid-range model, HTC’s 8S, is priced at 9,990 baht. The Lumia 620 is priced at 800 RM ($ 266) in Malaysia, one of Asia’s key mobile markets. HTC’s 8S launched in Malaysia at 999 RM.

[More from BGR: Clash of the bantams: The bloody smartphone battle that will take shape in 2013]

Nokia is the stronger brand in South-East Asia and HTC’s budget Windows model was expected to be at rough price parity during the 620 launch, not 20% above. Nokia’s Lumia 620 features display pixel density of 246 pixels per inch, a touch above the 233 pixels per inch that HTC’s 8S offers. The 620 also packs 8 GB of internal memory, twice as much as the 8S. Camera and video quality are roughly similar.

This is the golden opportunity for Nokia. It will probably take at least until June before RIM rolls out new BlackBerries priced under $ 300 in Asia; possibly late summer or autumn. Samsung and LG are a step behind Nokia in rolling out their Windows Phone 8 ranges. HTC’s first mid-range model doesn’t quite measure up to the 620 in value for money comparison. Apple’s (AAPL) rumored cheap iPhone is unlikely to arrive before September.

Nokia now has a shot at recapturing some of the power it used to have in the mid-range smartphone market. Back in 2006 through 2008 Nokia dominated the smartphone markets of Asia and Europe with absolute sovereignty, capturing market shares as high as 70% from India to Germany. Those days won’t return, but if the 620 clicks, Nokia just might have a shot at pumping the Lumia volume to 10 million units per quarter by autumn.

The relative market softness in the sub-$ 300 category due to the current weakness of RIM, LG, Sony (SNE) and HTC has opened the door. This February is going to be an absolutely crucial month for Nokia as it ramps up its most important Lumia phone during the traditionally dead period in Asia and Europe. If consumers don’t connect with this model at this price, the entire Windows Phone camp will face some very tough decisions.

This article was originally published on BGR.com

Gadgets News Headlines – Yahoo! News

Title Post: The aggressively priced Lumia 620 is Nokia’s make or break model
Url Post: http://www.news.fluser.com/the-aggressively-priced-lumia-620-is-nokias-make-or-break-model/
Link To Post : The aggressively priced Lumia 620 is Nokia’s make or break model
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment

Read More..

See Personal Pics of Rosie O'Donnell's Daughter Dakota

After welcoming her fifth child, the comedian gives fans an intimate glimpse into her mommy joy in a series of personal photos

Credit: Courtesy of Rosie O'Donnell

Updated: Thursday Jan 17, 2013 | 12:00 PM EST
By: Shanelle Rein-Olowokere

Subscribe Now

Read More..